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The growth factor BMP2 is used clinically to help form bone in difficult surgeries such as spinal fusions and fracture non-unions. In these surgeries, BMP2 is effective when used at milligram doses. However, this is roughly a million-fold more BMP2 …
We explore whether the cellular responses to an impact injury can affect cartilage integrity. We identified cell-mediated damage, which is in addition to the mechanical damage caused by the immediate impact of an injury. We used a cartilage explant injury …
Cellular Responses to Injury can Further Damage Cartilage Read more »
Our chapter on “Closed Joint ACL Disruption Murine Model of PTA” is published in “Post-Traumatic Arthritis: Pathogenesis Diagnosis and Management” edited by Steven Olson and Farshid Guilak. The book provides a comprehensive discussion of the current thinking on post-traumatic arthritis, …
Protease activity degrades joint tissues after injury, causing arthritis progression over time. A new imaging technology allows us to visualize protease activity in real-time in the knee joints of living mice. We see increased joint degradation within 1 day of an ACL tear. This is long before any cartilage damage …
Our recent article published in Arthritis Research & Therapy examines this question. We used our mouse model of PTOA that relies on ACL-rupture to create a joint injury, and examined changes in subchondral bone, osteophyte formation, cartilage degradation using the …