Cellular Responses to Injury can Further Damage Cartilage

We explore whether the cellular responses to an impact injury can affect cartilage integrity. We identified cell-mediated damage, which is in addition to the mechanical damage caused by the immediate impact of an injury. We used a cartilage explant injury model to demonstrate that when we prevent activation of primary response genes in cells, we can protect the injured cartilage from inflammation, apoptosis, and subsequent matrix degradation. Read more at the publishers site.

This manuscript was accepted for publication at the eCM Journal, a high quality not-for-profit open access journal published by scientists at the AO Foundation.