Our newest article is in the Journal of Orthopaedic Trauma’s “OTA Basic Science Focus Issue“. Dr Joseph Borrelli organized an excellent discussion by researchers and traumatologists on articular cartilage injuries and potential remedies. We contributed a section on early injury …
Views on Cartilage Injury and Potential Remedies Read more →
The growth factor BMP2 is used clinically to help form bone in difficult surgeries such as spinal fusions and fracture non-unions. In these surgeries, BMP2 is effective when used at milligram doses. However, this is roughly a million-fold more BMP2 …
We explore whether the cellular responses to an impact injury can affect cartilage integrity. We identified cell-mediated damage, which is in addition to the mechanical damage caused by the immediate impact of an injury. We used a cartilage explant injury …
Cellular Responses to Injury can Further Damage Cartilage Read more →
Our chapter on “Closed Joint ACL Disruption Murine Model of PTA” is published in “Post-Traumatic Arthritis: Pathogenesis Diagnosis and Management” edited by Steven Olson and Farshid Guilak. The book provides a comprehensive discussion of the current thinking on post-traumatic arthritis, …
This study is an interesting systematic review and meta-analysis of arthroscopic knee surgeries performed on middle-aged adults with knee pain. The authors conclude that knee surgeries offer only mild short term benefits, and can cause harm. Event the short-term benefits …
Knee Surgery for OA – Some Harm, Little Benefit, Exercise is Better! Read more →